Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
USERS' SCORE
Good
Based on 24 Reviews
8.3
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
8
We explored how N(1)-methylnicotinamide (MNA+) can improve blood vessel relaxation, particularly in those with high cholesterol. The study involved both healthy and hypercholesterolemic participants taking MNA+ and demonstrated significant improvements in flow-mediated dilation, which is linked to enhanced nitric oxide (NO) production.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
Most Useful Reviews
8.8
Supports mood
The complete vitamin B complex is excellent for the nervous system and aids those experiencing numbness. It benefits the eyes, skin, and internal organs, raising good cholesterol while reducing bad cholesterol. It enhances immunity and energy levels. I took it to alleviate migraine attacks, and it worked wonders, also improving my skin and nails. The high-quality package lasts a month for daily doses.
9.5
Improved mood
Vitamins for fatigue! This product helps me effectively manage stress. Taking it twice daily yields immediate results: sleep improves, efficiency rises, and mood enhances. I've been using this for two years, completing courses thrice a year. One package lasts a month. I recommend B-Complex from Life Extension for supporting the body under pressure and during seasonal changes. These B vitamins are easily digestible and appear to aid in lowering cholesterol levels.9.5
Health transformation
I've noticed a significant difference in my health, mood, and overall well-being since taking this vitamin. My energy levels have increased, and I can now manage activities like climbing stairs without my heart racing. This product has been life-changing for me.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
- All Researches
9
We explored the effectiveness of a dietary supplement combining red yeast rice and other natural compounds for lowering cholesterol in children with high cholesterol.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
9
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
9
We examined the effectiveness of nutraceuticals in lowering cholesterol levels and blood pressure for patients with high cholesterol and hypertension. Over six months, 66 participants took a daily tablet containing red yeast rice, policosanol, berberine, folic acid, and coenzyme Q10 alongside usual diet management.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
User Reviews
USERS' SCORE
Good
Based on 24 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Supports mood
The complete vitamin B complex is excellent for the nervous system and aids those experiencing numbness. It benefits the eyes, skin, and internal organs, raising good cholesterol while reducing bad cholesterol. It enhances immunity and energy levels. I took it to alleviate migraine attacks, and it worked wonders, also improving my skin and nails. The high-quality package lasts a month for daily doses.
9.5
Improved mood
Vitamins for fatigue! This product helps me effectively manage stress. Taking it twice daily yields immediate results: sleep improves, efficiency rises, and mood enhances. I've been using this for two years, completing courses thrice a year. One package lasts a month. I recommend B-Complex from Life Extension for supporting the body under pressure and during seasonal changes. These B vitamins are easily digestible and appear to aid in lowering cholesterol levels.9.5
Health transformation
I've noticed a significant difference in my health, mood, and overall well-being since taking this vitamin. My energy levels have increased, and I can now manage activities like climbing stairs without my heart racing. This product has been life-changing for me.
9.5
Effect on anxiety
Highly recommended! I noticed significant improvements in conditions such as seborrheic dermatitis, scalp itching, skin inflammation, allergies, and anxiety disorders. This product stands out compared to other supplements available. The high content means starting with one grain is advisable to prevent niacin flush, which, though alarming, subsides within hours. After experiencing niacin flush, my anxiety and depression improved significantly.
8.5
Reduced homocysteine
An excellent complex for stress and reducing homocysteine! This is my third purchase. One should consume it an hour after meals. Water-soluble B vitamins are crucial for turning proteins, fats, and carbohydrates into energy. Despite their high consumption during stress and diets, overdoses are rare. I've noticed a decrease in homocysteine from 10.5 to 7.5 units in two months. My family reported no allergic reactions.
Frequently Asked Questions
8
Age process slowdown
I took this B vitamin complex on a nutritionist's advice and found the quality to be excellent. After several weeks, I noticed improved sleep, increased working capacity, and a better mood. It appears to help in slowing aging, enhancing the immune system and normalising blood pressure, as well as cholesterol levels.
8.5
Reduced homocysteine
An excellent complex for stress and reducing homocysteine! This is my third purchase. One should consume it an hour after meals. Water-soluble B vitamins are crucial for turning proteins, fats, and carbohydrates into energy. Despite their high consumption during stress and diets, overdoses are rare. I've noticed a decrease in homocysteine from 10.5 to 7.5 units in two months. My family reported no allergic reactions.
9.5
Health transformation
I've noticed a significant difference in my health, mood, and overall well-being since taking this vitamin. My energy levels have increased, and I can now manage activities like climbing stairs without my heart racing. This product has been life-changing for me.
9.5
Effect on anxiety
Highly recommended! I noticed significant improvements in conditions such as seborrheic dermatitis, scalp itching, skin inflammation, allergies, and anxiety disorders. This product stands out compared to other supplements available. The high content means starting with one grain is advisable to prevent niacin flush, which, though alarming, subsides within hours. After experiencing niacin flush, my anxiety and depression improved significantly.
8.8
Energy boost
Amazing! Ignore the "rashes and reactions"; that’s just niacin flushing, which is harmless. After months of health issues, I learned I had extremely low B vitamins. After just two doses, my energy drastically improved, and I was finally able to get out of bed. Symptoms of peripheral neuropathy vanished after a week, and my stomach acid production started to return, aided by zinc. Lowering the dose helped manage initial flushing. My experience improved significantly.
0
No benefits observed
I had high hopes, but unfortunately, nothing improved. Beyond the bright green urine, I noted no positive effects whatsoever. 
8.8
Iron deficiency relief
I ordered this complex for myself and my parents. The doctor prescribed B vitamins due to iron deficiency anaemia, but I found this complete bioactive complex, which seems to contain everything needed. I am very pleased with its effects, as I do not observe any side effects and feel great! The price-to-quality ratio is very pleasing. For optimal absorption, it is recommended to also take magnesium and vitamin C.
7.5
Better energy overall
Good B-COMPLEX! This high-quality supplement has significantly improved my aunt’s wellbeing since she started taking it a month ago. However, for optimal effects, it may be better to take different B vitamins separately to adjust dosages as necessary. Always consult your doctor first to ensure it meets your specific needs.
8.8
Effective for cholesterol
Daily B vitamins are essential. My parents noticed benefits, but after taking on an empty stomach, I experienced flushing reactions. However, it’s harmless, as stated by Dr. Berger. Niacin aids in reducing low-density cholesterol and triglycerides without flushing effects. Switching to post-meal consumption eliminated the itching for me. I find this product effective and will continue purchasing it.
9.5
Improved mood
Vitamins for fatigue! This product helps me effectively manage stress. Taking it twice daily yields immediate results: sleep improves, efficiency rises, and mood enhances. I've been using this for two years, completing courses thrice a year. One package lasts a month. I recommend B-Complex from Life Extension for supporting the body under pressure and during seasonal changes. These B vitamins are easily digestible and appear to aid in lowering cholesterol levels.9
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
9
We examined the effectiveness of nutraceuticals in lowering cholesterol levels and blood pressure for patients with high cholesterol and hypertension. Over six months, 66 participants took a daily tablet containing red yeast rice, policosanol, berberine, folic acid, and coenzyme Q10 alongside usual diet management.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
References
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. doi:10.3390/biom14121608
- Geng X, Lin Z, Zheng Z, Lin Q, Sun T, et al. Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults. Nutr Res. 2024;131:54. doi:10.1016/j.nutres.2024.09.006
- Shoman ME, Aboelez MO, Shaykhon MSA, Ahmed SA, Abuo-Rahma GEA, et al. New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity. Mol Divers. 2021;25:673. doi:10.1007/s11030-020-10039-9
- Heinz T, Schuchardt JP, Möller K, Hadji P, Hahn A. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nutr Res. 2016;36:1162. doi:10.1016/j.nutres.2016.07.005
- Qin X, Li J, Spence JD, Zhang Y, Li Y, et al. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients. Stroke. 2016;47:2805.
- Mazza A, Lenti S, Schiavon L, Zuin M, D'Avino M, et al. Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk. Adv Ther. 2015;32:680. doi:10.1007/s12325-015-0229-x
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. doi:10.1186/1475-2891-12-7
- Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28
- Domagala TB, Szeffler A, Dobrucki LW, Dropinski J, Polanski S, et al. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels. Hypertension. 2012;59:825. doi:10.1161/HYPERTENSIONAHA.111.183210
- Marazzi G, Cacciotti L, Pelliccia F, Iaia L, Volterrani M, et al. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Adv Ther. 2011;28:1105. doi:10.1007/s12325-011-0082-5
